The Effect of P-Glycoprotein Inhibition and Activation on the Absorption and Serum Levels of Cyclosporine and Tacrolimus in Rats

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Yiğitaslan S., Erol K., Çengelli Ünel Ç.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.25, ss.237-242, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2016
  • Doi Numarası: 10.17219/acem/35254
  • Dergi Adı: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.237-242
  • Anahtar Kelimeler: P-glycoprotein, cyclosporine, tacrolimus, everted sac, DRUG-INTERACTIONS, SMALL-INTESTINE, GASTROINTESTINAL ABSORPTION, EFFLUX, RIFAMPICIN, PHARMACOKINETICS, BIOAVAILABILITY, METABOLISM, EXPRESSION, SUBSTRATE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background. Permeability glycoprotein (P-glycoprotein or P-gp) plays an important role in the intestinal absorption of the immunosuppressive agents: cyclosporine and tacrolimus.