The Effect of P-Glycoprotein Inhibition and Activation on the Absorption and Serum Levels of Cyclosporine and Tacrolimus in Rats

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Yiğitaslan S., Erol K., Çengelli Ünel Ç.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.25, pp.237-242, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25
  • Publication Date: 2016
  • Doi Number: 10.17219/acem/35254
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.237-242
  • Keywords: P-glycoprotein, cyclosporine, tacrolimus, everted sac, DRUG-INTERACTIONS, SMALL-INTESTINE, GASTROINTESTINAL ABSORPTION, EFFLUX, RIFAMPICIN, PHARMACOKINETICS, BIOAVAILABILITY, METABOLISM, EXPRESSION, SUBSTRATE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background. Permeability glycoprotein (P-glycoprotein or P-gp) plays an important role in the intestinal absorption of the immunosuppressive agents: cyclosporine and tacrolimus.