Fetal echogenic bowel in association with Zellweger syndrome

Aydemir Ö., Kavurt S., Esin S., Kandemir O., BAŞ A. Y., Demirel N.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, cilt.40, sa.6, ss.1799-1802, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 6
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/jog.12379
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1799-1802
  • Anahtar Kelimeler: fetal echogenic bowel, neurometabolic disease, peroxisomal disorders, prenatal ultrasonography, Zellweger syndrome
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Increased echogenicity of fetal bowel in the second trimester obstetrical ultrasound has been described in association with several pathologic conditions, such as growth restriction, aneuploidy, cystic fibrosis, congenital infections, and gastrointestinal malformations. Zellweger syndrome (ZS) is the prototype of peroxisomal disorders characterized by craniofacial dysmorphism and severe neurologic abnormalities. We report two cases with fetal echogenic bowel (FEB) but no associated anomalies and normal fetal growth. After birth, clinical and laboratory findings led to diagnosis of ZS. Association of FEB with neurometabolic disorders is limited to a few case reports in the medical literature. To the best of our knowledge, this is the first report of ZS associated with FEB.