Istanbul is an earthquake prone city and has experienced many earthquakes throughout history. Also, Istanbul is threatened by a 65 % probability of a devastating earthquake in the next 30 years. In order to reduce the disaster risk in Istanbul, structure of disaster management must be strengthened. In this study, importance weights of districts of Istanbul are determined and risk maps are generated by Analytic Hierarchy Process (AHP) including criteria of socio-economic, building, structure, geographical and geological features, and infrastructure and sub-criteria of these criteria. We consider that results of this study can provide a decision support framework for policy makers to reflect critically on possible risk mitigation plans. The results would be used as guidance for practitioners.