Does plateletpheresis induce a hypercoagulable state? A global assessment of donor?s hemostatic system by ROTEM

Akay O. M., Tastekin F., ÇOLAK E.

PLATELETS, cilt.30, sa.8, ss.989-993, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/09537104.2018.1542126
  • Dergi Adı: PLATELETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.989-993
  • Anahtar Kelimeler: Apheresis, coagulation, rotation thromboelastometry, 2 CELL SEPARATORS, THROMBOEMBOLIC COMPLICATIONS, COAGULATION PARAMETERS, HEALTHY DONORS, THROMBOELASTOMETRY, APHERESIS, RESECTION
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Since there is still debate on the effects of plateletpheresis on coagulation system, we aimed to perform a global assessment of donor?s hemostatic function undergoing plateletpheresis by rotation thromboelastometry (ROTEM) analysis and to clarify if plateletpheresis procedure induces a hypercoagulable state. Thirty male plateletpheresis donors were included in the study. Four blood samples were drawn at different time intervals: before the beginning of the apheresis procedure; immediately after the completion of the apheresis procedure; 24?h and 7?days after the apheresis procedure. ?Hypercoagulability? was diagnosed readily by having an accelerated clot formation, as evidenced by shortening of CFT and an increase of the clot strength, as evidenced by increasing of MCF. In INTEM assay, CFT value after apheresis was significantly prolonged compared with baseline value while CFT value 7?days after apheresis was significantly shortened compared with values immediately and 24?h after apheresis (p?