In-vivo Biocompatibility Evaluation of Different Self-Adhering Composite Resins on Wister Rats

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Saygin A., ÜNAL M., KOÇ T., Ipek I., Candan M.

JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY, vol.34, no.6, pp.579-585, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.2494/photopolymer.34.579
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, INSPEC, Metadex
  • Page Numbers: pp.579-585
  • Keywords: Biocompatibility, Self-adhering composite, Subcutaneous tissue, Wistar albino rat, DENTIN BONDING AGENTS, CYTOTOXICITY, COMPONENTS, DIFFUSION, TISSUE, VITRO
  • Eskisehir Osmangazi University Affiliated: No


This study aimed to compare the biocompatibility of two different self-adhering flowable resin composites (SAFCs). 54 polyethylene tubes filled with two different SAFCs [Group V: Vertise Flow (VF), Group F: Fusio Liquid Dentin (FLD), or Group C: empty (Control)] were implanted into the subcutaneous tissue of 18 rats. After 7, 30, and 90 days of implantation, the rats were euthanatized (n=6). The implanted materials were removed with the surrounding tissue for histologic evaluation. The subjects were evaluated in terms of inflammation, fibrous capsule thickness, necrosis, macrophage, and giant cell presence. When the SAFC groups and Group C were compared on days 7, 30, and 90, inflammation, fibrous capsule thickness, and macrophage on the 7th day were statistically significant (p<0.05). Statistically, the giant cell and macrophage criteria were statistically significant on the 7th, 30th, and 90th days in all groups (p<0.05). When the groups were evaluated on different days among themselves, significant differences were observed in terms of local tissue response (p<0.05), while necrosis was found to be statistically insignificant (p>0.05). Biocompatibility was found similar for the SAFCs. These materials used in the study have shown good biocompatibility in rats, and SAFCs can be considered suitable for all restorative treatments.