In vitro antibiofilm efficacy of farnesol against Candida species


Yapıcı M., Gürsu B. Y. , DAĞ İ.

International Microbiology, vol.24, no.2, pp.251-262, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1007/s10123-021-00162-4
  • Title of Journal : International Microbiology
  • Page Numbers: pp.251-262
  • Keywords: Farnesol, Biofilm, Candida, Electron microscopy

Abstract

© 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.Candida species are opportunistic fungi that can cause mucosal or invasive infections. Especially in biofilm-related infections, resistance is very high to anifungals; therefore more effective treatment strategies are needed. Farnesol(3,7,11-trimethyl-2,6,10-dodecatriene-1-ol) is the quorum sensing (QS) signal molecule and can interact with Candida species both as a QS molecule and as an exogenous agent. The aim of this study was to investigate the effects of farnesol on both the planktonic and biofilm forms of Candida species by colorimetric, microbiological, and electron microscopic methods. Obtained results demonstrated the inhibitory effect of farnesol on the planktonic and biofilm forms of Candida. Farnesol showed a biofilm-enhancing effect at lower concentrations. TEM findings showed the membrane and wall damage, vacuolization, or granulation in cells. SEM images confirmed biofilm reduction in pre-/post-biofilm applications as a result of farnesol treatment. In conclusion, farnesol can be used as an alternative agent to reduce the Candida biofilms, with future studies.