Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.

Gunduz, M.; Safak, C.; Kaygisiz, BİLGİN; Kosar, B.; Simsek, R.; Erol, K.; Linden, A.

doi:10.1055/s-0031-1299744

Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.

Gunduz M. G., Safak C., Kaygisiz B., Kosar B. C., Simsek R., Erol K., ...Daha Fazla

Arzneimittel-Forschung, cilt.62, sa.4, ss.167-75, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 62 Sayı: 4
Basım Tarihi: 2012
Doi Numarası: 10.1055/s-0031-1299744
Dergi Adı: Arzneimittel-Forschung
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.167-75
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.