Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.

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Gunduz M. G., Safak C., Kaygisiz B., Kosar B. C., Simsek R., Erol K., ...More

Arzneimittel-Forschung, vol.62, no.4, pp.167-75, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1055/s-0031-1299744
  • Journal Name: Arzneimittel-Forschung
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.167-75
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.