Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.

Creative Commons License

Gunduz M. G., Safak C., Kaygisiz B., Kosar B. C., Simsek R., Erol K., ...Daha Fazla

Arzneimittel-Forschung, cilt.62, sa.4, ss.167-75, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1055/s-0031-1299744
  • Dergi Adı: Arzneimittel-Forschung
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.167-75
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.