© 2021 ANP Publishing. All rights reserved.sexual dysfunction in men. Although the pathophysiology has not been clarified yet, psychological factors have been studied frequently. It may be useful to investigate the temperament and character characteristics of the patients in understanding the premature ejaculation, which has both biological and psychological dimensions. Neuroticism and harm avoidance dimensions are found to be associated with sexual dysfunction. In this study, temperament, character, sexual satisfaction, anxiety and depression levels of lifelong and acquired premature ejaculation patients are investigated. Method: Forty patients diagnosed with premature ejaculation and 40 controls were included in the study. The patient group was divided into two groups as lifelong (n= 20) and acquired (n= 20) subtypes. Sociodemographic data form, Temperament and Character Inventory, Golombok-Rust Sexual Satisfaction Scale, Hospital Anxiety and Depression Scale are applied. Results: Premature ejaculation patients had lower sexual satisfaction scores and higher fatigability sub-dimension scores of harm avoidance, comparing to the control group (p< 0.05). Discussion: Harm avoidance as a temperament feature, is associated with neurotransmitter structures, is a prominent parameter in sexual dysfunctions. Larger sampling and longitudinal studies are needed to investigate the relationship between sexual dysfunctions and harm avoidance.