EFFECTS OF CIPROFLOXACIN ON CHROMOSOMES, AND HEPATIC AND RENAL FUNCTIONS IN RATS


BASARAN A., EROL K., BASARAN N., GUNES H., ACIKALIN E., TIMURALP G., ...More

CHEMOTHERAPY, vol.39, no.3, pp.182-188, 1993 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 1993
  • Doi Number: 10.1159/000239124
  • Title of Journal : CHEMOTHERAPY
  • Page Numbers: pp.182-188

Abstract

In the present study, ciprofloxacin, a fluoroquinolone antibiotic, was evaluated in vivo. The toxic effects of ciprofloxacin (20 and 200 mg/kg/day) on kidney and liver functions, and on chromosomes were investigated in rats. 20 mg/kg/day ciprofloxacin did not significantly affect urine composition, serum enzyme levels and the haematocrit, affecting only creatinine clearance. The 200 mg/kg/day dose increased urine volume, serum creatinine and and creatinine clearance. Ciprofloxacin at both doses had no significant numerical effect on chromosomes, but there was a statistically significant dose-dependent increase in chromatid-type breakage. Significant histological changes in the liver and kidney were not observed.