EFFECTS OF CIPROFLOXACIN ON CHROMOSOMES, AND HEPATIC AND RENAL FUNCTIONS IN RATS

BASARAN A., EROL K., BASARAN N., GUNES H., ACIKALIN E., TIMURALP G., ...Daha Fazla

CHEMOTHERAPY, cilt.39, sa.3, ss.182-188, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1159/000239124
  • Dergi Adı: CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.182-188
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In the present study, ciprofloxacin, a fluoroquinolone antibiotic, was evaluated in vivo. The toxic effects of ciprofloxacin (20 and 200 mg/kg/day) on kidney and liver functions, and on chromosomes were investigated in rats. 20 mg/kg/day ciprofloxacin did not significantly affect urine composition, serum enzyme levels and the haematocrit, affecting only creatinine clearance. The 200 mg/kg/day dose increased urine volume, serum creatinine and and creatinine clearance. Ciprofloxacin at both doses had no significant numerical effect on chromosomes, but there was a statistically significant dose-dependent increase in chromatid-type breakage. Significant histological changes in the liver and kidney were not observed.