Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats


Creative Commons License

BAYRAMOĞLU G., ŞENTÜRK H., Bayramoglu A., UYANOĞLU M., Colak S., Ozmen A., ...Daha Fazla

CYTOTECHNOLOGY, cilt.66, sa.2, ss.251-257, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s10616-013-9563-5
  • Dergi Adı: CYTOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.251-257
  • Anahtar Kelimeler: Carvacrol, Diabetes, Streptozotocin, Rat, Liver, BLOOD-GLUCOSE, ISCHEMIA-REPERFUSION, CHOLESTEROL LEVELS, OXIDATIVE STRESS, STREPTOZOTOCIN, EXTRACT, INJURY, LIVER, L.
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Little is known about the protective effects of carvacrol on the symptoms of streptozotocin induced diabetes in rats. Hence, this present study was designed to evaluate the protective effect of the strong antioxidant, carvacrol, on the symptoms of streptozotocin induced diabetes in rats. Carvacrol at the doses of 25 and 50 mg/kg body weight were orally administered to diabetic rats for a period of 7 days after the onset of diabetes. Food-water intake and body weight changes were daily recorded. Biochemical parameters such as serum glucose, insulin, total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase were measured. Although treatment of diabetic rats with oral administration of carvacrol resulted in a slight reduction in serum glucose level and significant reduction in serum total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase in comparison with diabetic control rats, there were no significant differences in serum insulin levels, foodwater intake values and body weight changes. Despite the inadequacy of carvacrol on diabetes treatments, it was determined to have at least a partially protective role on liver enzymes.