Anti-inflammatory effects of oral and intraperitoneal administration of cerium oxide nanoparticles on experimental hepatic ischemia-reperfusion injury
TURKISH JOURNAL OF SURGERY, vol.38, no.3, pp.255-265, 2022 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 38 Issue: 3
- Publication Date: 2022
- Doi Number: 10.47717/turkjsurg.2022.5620
- Journal Name: TURKISH JOURNAL OF SURGERY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
- Page Numbers: pp.255-265
- Keywords: Ischemia reperfusion, cerium oxide nanoparticles (CONPs), mouse, oxidative stress, inflammation, ISCHEMIA/REPERFUSION INJURY, MECHANISMS, SEVOFLURANE, INHIBITION, TISSUE, MODEL
- Eskisehir Osmangazi University Affiliated: No
Abstract
Objective: Hepatic ischemia-reperfusion (IR) injury occurs in liver surgery, resection, and transplantation. Reactive oxygen species (ROS) produced following IR starts the cascade of cell damage, necrosis/apoptosis, and proinflammatory responses by activating intracellular signaling cascade to drive hepatocellular damage. Cerium oxide nanoparticles (CONPs) act as anti-inflammatory and antioxidant agents. Thus, we evaluated the protective effects of oral (o.g.) and intraperitoneal (i.p.) administration of CONPs on hepatic IR injury.