The effect of intrathecal medetomidine on small bowel transit in the rat

Bilir L., Yelken B., Gulec S., Bilir A., Ekemen S.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, vol.20, no.11, pp.911-915, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 11
  • Publication Date: 2003
  • Doi Number: 10.1097/00003643-200311000-00009
  • Journal Name: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.911-915
  • Keywords: ADRENERGIC AGONISTS, adrenergic alpha-agonists, medetomidine, DIGESTIVE PHYSIOLOGY, gastrointestinal motility, VASCULAR DISEASES, ISCHAEMIA, colitis, ischaemic, SMALL INTESTINAL TRANSIT, GASTROINTESTINAL TRANSIT, EPIDURAL-ANESTHESIA, MOTILITY, DEXMEDETOMIDINE, CLONIDINE, ANALGESIA, AGONISTS, ILEUS, ANTINOCICEPTION
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background and objective: Gastrointestinal motility is influenced by abdominal trauma, laparotomy and particularly by intestinal ischaemia. The reflex inhibition of gastrointestinal motility is mediated mainly by the sympathetic nervous system. There are reports on the effects of systemically applied alpha(2)-adrenoceptor agonists on gastric emptying and recovery of bowel motility, but the effect of spinally applied alpha(2)-adrenoceptor agonists on intestinal motility has not been studied. The aim of this study was to investigate the effects of intrathecal medetomidine on gastrointestinal transit in rats after transient intestinal ischaemia.