The effect of intrathecal medetomidine on small bowel transit in the rat

Bilir L., Yelken B., Gulec S., Bilir A., Ekemen S.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, cilt.20, sa.11, ss.911-915, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 11
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1097/00003643-200311000-00009
  • Dergi Adı: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.911-915
  • Anahtar Kelimeler: ADRENERGIC AGONISTS, adrenergic alpha-agonists, medetomidine, DIGESTIVE PHYSIOLOGY, gastrointestinal motility, VASCULAR DISEASES, ISCHAEMIA, colitis, ischaemic, SMALL INTESTINAL TRANSIT, GASTROINTESTINAL TRANSIT, EPIDURAL-ANESTHESIA, MOTILITY, DEXMEDETOMIDINE, CLONIDINE, ANALGESIA, AGONISTS, ILEUS, ANTINOCICEPTION
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background and objective: Gastrointestinal motility is influenced by abdominal trauma, laparotomy and particularly by intestinal ischaemia. The reflex inhibition of gastrointestinal motility is mediated mainly by the sympathetic nervous system. There are reports on the effects of systemically applied alpha(2)-adrenoceptor agonists on gastric emptying and recovery of bowel motility, but the effect of spinally applied alpha(2)-adrenoceptor agonists on intestinal motility has not been studied. The aim of this study was to investigate the effects of intrathecal medetomidine on gastrointestinal transit in rats after transient intestinal ischaemia.