The Frequency of Metabolic Syndrome and Serum Osteopontin Levels in Survivors of Childhood Acute Lymphoblastic Leukemia

Ozdemir Z. C., Kar Y. D., Demiral M., SIRMAGÜL B., BÖR Ö., KIREL B.

JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY, cilt.7, sa.4, ss.480-487, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1089/jayao.2017.0129
  • Dergi Adı: JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.480-487
  • Anahtar Kelimeler: metabolic syndrome, childhood, acute lymphoblastic leukemia, survivor, osteopontin, LONG-TERM SURVIVORS, ADIPOSE-TISSUE, OBESITY, CHILDREN, CANCER, EXPRESSION, RISK, CIRCUMFERENCE, ADOLESCENTS, TARGET
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Purpose: Metabolic syndrome (MetS) and obesity have increasingly been reported in survivors of childhood cancer. Osteopontin (OPN) is primarily synthesized in adipose tissue and is thought to have a role in obesity and the development of insulin resistance (IR). The aim of this study was to investigate the frequency of MetS in survivors of acute lymphoblastic leukemia (ALL) and to establish the relationship between serum OPN levels and anthropometric measurements and glucose metabolism.