The Frequency of Metabolic Syndrome and Serum Osteopontin Levels in Survivors of Childhood Acute Lymphoblastic Leukemia

Ozdemir Z. C., Kar Y. D., Demiral M., SIRMAGÜL B., BÖR Ö., KIREL B.

JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY, vol.7, no.4, pp.480-487, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1089/jayao.2017.0129
  • Journal Name: JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.480-487
  • Keywords: metabolic syndrome, childhood, acute lymphoblastic leukemia, survivor, osteopontin, LONG-TERM SURVIVORS, ADIPOSE-TISSUE, OBESITY, CHILDREN, CANCER, EXPRESSION, RISK, CIRCUMFERENCE, ADOLESCENTS, TARGET
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Purpose: Metabolic syndrome (MetS) and obesity have increasingly been reported in survivors of childhood cancer. Osteopontin (OPN) is primarily synthesized in adipose tissue and is thought to have a role in obesity and the development of insulin resistance (IR). The aim of this study was to investigate the frequency of MetS in survivors of acute lymphoblastic leukemia (ALL) and to establish the relationship between serum OPN levels and anthropometric measurements and glucose metabolism.