Prevention of Burn Wound Progression by Mesenchymal Stem Cell Transplantation: Deeper Insights Into Underlying Mechanisms

ABBAS O. L., Ozatik O., GÖNEN Z. B., ÖĞÜT S., ENTOK E., Ozatik F. Y., ...More

ANNALS OF PLASTIC SURGERY, vol.81, no.6, pp.715-724, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1097/sap.0000000000001620
  • Journal Name: ANNALS OF PLASTIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.715-724
  • Keywords: angiogenesis, apoptosis, burn, mesenchymal stem cell, oxidative stress, stasis zone, PARTIAL THICKNESS BURNS, OXIDATIVE STRESS, FREE-RADICALS, INJURY, APOPTOSIS, DEATH, SKIN, ZONE, REGENERATION, NECROSIS
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Introduction Burns are dynamic wounds that may present a progressive expansion of necrosis into the initially viable zone of stasis. Therefore, salvage of this zone is a major subject of focus in burn research. The beneficial effects of mesenchymal stem cells (MSCs) on the survival of the zone of stasis have been previously documented. However, many gaps still exist in our knowledge regarding the underlying protective mechanisms. Hence, this study was designed to evaluate the pathophysiological basis of MSCs in the prevention of burn wound progression.