Some pyridazinone and phthalazinone derivatives and their vasodilator activities

Demirayak S., Karaburun A., Kayagil I., Erol K., Sirmagul B.

ARCHIVES OF PHARMACAL RESEARCH, vol.27, no.1, pp.13-18, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1007/bf02980038
  • Journal Name: ARCHIVES OF PHARMACAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.13-18
  • Keywords: pyridazinone, phthalazinone, vasodilator activity, PLATELET-AGGREGATION, AGENTS, INHIBITORS, PHOSPHODIESTERASE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4aminophenyl)-1(2H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.