Akademik Veri Yönetim Sistemi
European Journal of Gynaecological Oncology, cilt.38, sa.5, ss.760-763, 2017 (SCI-Expanded)
Purpose of investigation: In this study, epidural local anesthetic drugs are scheduled to examine their effects on the coagulation cascade. Materials and Methods: A total of 40 patients with gynecologic tumors were eligible. Epidural catheter was introduced into the epidural space of all patients. The patients were randomized into control and study groups. Before the induction of anesthesia, saline five cc, in control group and 25 mg bupivacaine was given via epidural catheter in study group. An epidural morphine infusion (0.2 mg/hour) was started in control group and an epidural infusion (0.2 mg/hour morphine + 0.75 mg/hour bupivacaine) was in study group. Before induction of anesthesia and postoperative 24 hours, thromboelastometry (TEG) analysis was performed. Results: Ellagic acid/phospholipid activation clotting time (INTEM CT), which was measured in the postoperative period, was significantly shorter in study group. Conclusion: Bupivacaine causes platelet dysfunction induced by various agonists, while neither this primary hemostatic abnormality nor other coagulation abnormalities can be detected by rotation thromboelastometry (ROTEM).