Ceylan S., Kürkçüoğlu E., Kandemir T.
Osmangazi Tıp Dergisi, cilt.48, sa.Öğrenci Özel Sayısı 2026, ss.64-70, 2026 (TRDizin)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
48
Sayı:
Öğrenci Özel Sayısı 2026
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Basım Tarihi:
2026
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Doi Numarası:
10.20515/otd.1990954
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Dergi Adı:
Osmangazi Tıp Dergisi
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Derginin Tarandığı İndeksler:
TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.64-70
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Eskişehir Osmangazi Üniversitesi Adresli:
Evet
Özet
Haemostasis is a complex physiological process involving vascular responses, platelet activation and coagulation cascade interactions that collectively maintain vascular integrity following tissue injury. Despite substantial advances in surgical techniques and perioperative care, intraoperative and postoperative bleeding remain major challenges in modern surgery. Consequently, topical haemostatic agents have evolved from simple passive materials to advanced biologically active, flowable, sealant-based and regenerative platform. This review provides a mechanism-oriented overview of topical haemostatic agents and their clinical applications through a structured classification framework integrated with the physiological basis of coagulation. A narrative review of currently available topical haemostatic agents was performed, classifying agents into five major categories according to material composition, mechanism of action and functional characteristics: mechanical scaffold haemostatic agents, biologically active haemostatic agents, flowable haemostatic agents, sealant and adhesive haemostatic agents and emerging regenerative haemostatic technologies. Mechanical scaffold agents remain foundational tools for routine bleeding control, whereas biologically active and flowable haemostats offer enhanced efficacy in complex bleeding environments. Sealant and adhesive haemostats extend functionality beyond haemostasis towards tissue reinforcement and leakage prevention. Emerging regenerative technologies represent a developing frontier that may integrate bleeding control with tissue repair.