New Procaspase Activating Compound (PAC-1) Like Molecules as Potent Antitumoral Agents Against Lung Cancer

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YURTTAŞ L., Ozturk O., CANTÜRK Z.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.16, no.6, pp.645-655, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 16 Issue: 6
• Publication Date: 2019
• Doi Number: 10.2174/1570180815666180926113040
• Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.645-655
• Eskisehir Osmangazi University Affiliated: No

Abstract

Background: In this study, novel ortho-hydroxy N-acyl hydrazone moiety including compounds (3a-l) were designed, based on procaspase activating compound (PAC-1) which is a small molecule known with antitumor activity. The antitumor activity was evaluated on A549 (human lung cancer cell line) and CCD 19Lu (human lung normal cell line).