THE EFFECT OF VASOACTIVE-INTESTINAL-PEPTIDE (VIP) ON SUPEROXIDE-DISMUTASE AND CATALASE ACTIVITIES IN RENAL TISSUES OF RATS EXPOSED TO HEMORRHAGIC ISCHEMIA-REPERFUSION


UZUNER K., TUNCEL N., AYDIN Y., TUNCEL M., GURER F., BENLI P., ...More

PEPTIDES, vol.16, no.5, pp.911-915, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 5
  • Publication Date: 1995
  • Doi Number: 10.1016/0196-9781(95)00055-o
  • Journal Name: PEPTIDES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.911-915
  • Keywords: ANTIOXIDANT ENZYMES, REPERFUSION INJURY, OXYGEN-DERIVED FREE RADICALS, HEMORRHAGIC SHOCK, KIDNEY PROTECTION, INJURY, SHOCK, LUNG
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

The effect of vasoactive intestinal peptide (VIP) on the activities of superoxide dismutase and catalase was investigated in renal tissues of rats exposed to 30% hemorrhage followed by reperfusion. In addition to enzyme activities, renal tissues were also histologically evaluated. Thirty percent hemorrhage had no significant effect on the activity of either enzyme. Reperfusion altered the activity of renal catalase but not of superoxide dismutase. On the other hand, administration of VIP (25 ng . kg(-1)) together with shed blood retransfusion protected the renal tissue from hemorrhagic ischemia-reperfusion injury without increasing superoxide dismutase and catalase activity. These results seem to be related either to the inhibitory effect of VIP on production or quenching activity of some reactive oxygen species. In conclusion, VIP may be a novel promising therapeutic approach toward defenses against hemorrhagic ischemia-reperfusion injury as an antioxidant.