Protective effect of erythropoietin on renal ischemia and reperfusion injury

Ates E., Yalcin A., Yilmaz S., Koken T., Tokyol C.

ANZ JOURNAL OF SURGERY, vol.75, no.12, pp.1100-1105, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1445-2197.2005.03612.x
  • Journal Name: ANZ JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1100-1105
  • Eskisehir Osmangazi University Affiliated: No

Abstract

Background: Multiple protective effects of erythropoietin (EPO), such as antiapoptotic, antioxidant, angiogenic and neuroprotective effects, against ischemia have been demonstrated in cell culture and animal models. Genistein is also a potent tyrosine kinase inhibitor. The aims of the present study were to evaluate the effects of EPO on renal ischemia/reperfusion injury and to determine the role of the tyrosine kinase pathway on this process.