Ceranib-2 inhibits HIF1-alpha gene expression and induces apoptosis in HepG2 cells


ÖZYURT R., ÖZKURT M., Karadag A., MERAL EVİŞ C. C., ERKASAP N.

CUKUROVA MEDICAL JOURNAL, vol.45, no.4, pp.1318-1325, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2020
  • Journal Name: CUKUROVA MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1318-1325
  • Keywords: HepG2, apoptosis, HIF-1 alpha, TNF-alpha, ASAH, PIVOTAL ROLE, CERAMIDE, ACTIVATION, INDUCTION, HYPOXIA, PLAYS, DEATH
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Purpose: The aim of this study is to investigate the apoptotic effect of a novel anti-cancer drug, ceranib-2 and impact on HIF-1 alpha levels on HepG2.