Ceranib-2 inhibits HIF1-alpha gene expression and induces apoptosis in HepG2 cells

ÖZYURT R., ÖZKURT M., Karadag A., MERAL EVİŞ C. C., ERKASAP N.

CUKUROVA MEDICAL JOURNAL, cilt.45, sa.4, ss.1318-1325, 2020 (ESCI, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2020
  • Dergi Adı: CUKUROVA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1318-1325
  • Anahtar Kelimeler: HepG2, apoptosis, HIF-1 alpha, TNF-alpha, ASAH, PIVOTAL ROLE, CERAMIDE, ACTIVATION, INDUCTION, HYPOXIA, PLAYS, DEATH
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this study is to investigate the apoptotic effect of a novel anti-cancer drug, ceranib-2 and impact on HIF-1 alpha levels on HepG2.