Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure

ÇAVUŞOĞLU, YÜKSEL; Mert, KADİR; Nadir, Aydin; MUTLU, FEZAN; Morrad, Bektas; ULUS, TANER

doi:10.2459/jcm.0000000000000033

Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure

ÇAVUŞOĞLU Y., Mert U., Nadir A., MUTLU F., Morrad B., ULUS T.

JOURNAL OF CARDIOVASCULAR MEDICINE, cilt.16, sa.9, ss.603-609, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 16 Sayı: 9
Basım Tarihi: 2015
Doi Numarası: 10.2459/jcm.0000000000000033
Dergi Adı: JOURNAL OF CARDIOVASCULAR MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.603-609
Anahtar Kelimeler: acute heart failure, dobutamine, ivabradine, CORONARY-ARTERY-DISEASE, RATE REDUCTION, CONTROLLED-TRIAL, BETA-BLOCKERS, FUNNY CURRENT, RISK-FACTOR, OUTCOMES, MORTALITY, DEATH
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background Ivabradine is a heart rate (HR)-lowering agent acting by inhibiting the I-f-channel. Dobutamine does increase the HR and has some deleterious effects on myocardium. So, we aimed to evaluate whether ivabradine treatment blunts a dobutamine-induced increase in HR.