Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure
JOURNAL OF CARDIOVASCULAR MEDICINE, vol.16, no.9, pp.603-609, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 16 Issue: 9
- Publication Date: 2015
- Doi Number: 10.2459/jcm.0000000000000033
- Journal Name: JOURNAL OF CARDIOVASCULAR MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.603-609
- Keywords: acute heart failure, dobutamine, ivabradine, CORONARY-ARTERY-DISEASE, RATE REDUCTION, CONTROLLED-TRIAL, BETA-BLOCKERS, FUNNY CURRENT, RISK-FACTOR, OUTCOMES, MORTALITY, DEATH
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
Background Ivabradine is a heart rate (HR)-lowering agent acting by inhibiting the I-f-channel. Dobutamine does increase the HR and has some deleterious effects on myocardium. So, we aimed to evaluate whether ivabradine treatment blunts a dobutamine-induced increase in HR.