Pyridine-2,5-dicarboxylate complexes with 2,2'-bipyridine and Co(II), Zn(II), Cu(II): syntheses, characterization, antimicrobial, and cytotoxic effects

ÇOLAK A. T., ÇOLAK F., Oztopcu-Vatan P., Akduman D., KABADERE S., Uyar R.

MEDICINAL CHEMISTRY RESEARCH, cilt.22, sa.9, ss.4376-4383, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 9
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00044-012-0446-7
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4376-4383
  • Anahtar Kelimeler: Pyridine-2, 5-Dicarboxylate complexes, Antimicrobial activity, Cytotoxicity, Glioma, TRANSITION-METAL-COMPLEXES, RAY CRYSTAL-STRUCTURES, COORDINATION POLYMERS, HYDROTHERMAL SYNTHESIS, MANGANESE(II) COMPLEXES, MAGNETIC-PROPERTIES, ACID, DNA, FLUORESCENCE, COPPER(II)
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, three novel mononuclear M(II)-pyridine-2,5-dicarboxylate (M = Co(II), Cu(II), and Zn(II)) complexes with pyridine-2,5-dicarboxylic acid or (isocinchomeronic acid, H(2)pydc) and 2,2'-bipyridine (bipy), [Co(pydc)(bipy)(2)]center dot 5H(2)O (1), [Cu(pydc)(bipy)(2)]center dot 6H(2)O (3), and [Zn(pydc)(bipy)(2)]center dot 6H(2)O (4) have been synthesized. Elemental, thermal, and mass analysis; magnetic susceptibilities; molar conductance; IR and UV/vis spectroscopic studies have been performed to characterize the complexes. Subsequently, the results of antimicrobial activity of the two ligands H(2)pydc and bipy, and the four compounds (1), (2), (3), and (4) were obtained by the agar disk diffusion method. Furthermore, the cytotoxic activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide viability assay for 24 and 48 h on rat glioma cells (C6).