Food protein-induced allergic proctocolitis in infants is associated with low serum levels of macrophage inflammatory protein-3a

Koksal B. T., BARIŞ Z., Sencelikel T., Ozcay F., Ozbek O. Y.

Journal of Pediatric Gastroenterology and Nutrition, cilt.78, sa.2, ss.211-216, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1002/jpn3.12069
  • Dergi Adı: Journal of Pediatric Gastroenterology and Nutrition
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, Veterinary Science Database
  • Sayfa Sayıları: ss.211-216
  • Anahtar Kelimeler: allergic proctocolitis, chemokines, food allergy, pathogenesis of proctocolitis
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Food protein-induced allergic proctocolitis (FPIAP) is a nonimmunoglobulin (IgE)-mediated food hypersensitivity and the exact mechanisms that cause FPIAP are unknown. Chemokines play crucial roles in the development of allergic diseases. Objective: To examine serum levels of a group of chemokines in infants with FPIAP. Methods: In 67 infants with FPIAP and 65 healthy infants, we measured serum levels of mucosa-associated epithelial chemokine (MEC/CCL28), thymus-expressed chemokine (TECK/CCL25), CX3CL1 and macrophage inflammatory protein (MIP)-3a/CCL20. Results: Infants with FPIAP had a lower median value of MIP3a/CCL20 than healthy infants [0.7 (0–222) vs. 4 (0–249) pg/mL, respectively] (p < 0.001). Infants with MIP3a/CCL20 levels ≤0.95 pg/mL have 13.93 times more risk of developing FPIAP than infants with MIP3a/CCL20 levels >0.95 pg/mL. Serum MEC/CCL28, TECK/CCL25, and CX3CL1 levels were similar between the infants with FPIAP and the control group. Conclusion: MIP3a/CCL20 serum levels were reduced in infants with FPIAP compared with healthy controls. Whether this finding has a role in pathogenesis remains to be determined.