Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies

KILIÇ F. S., SIRMAGÜL B., YILDIRIM E., Oner S., Erol K.

INDIAN JOURNAL OF MEDICAL RESEARCH, cilt.135, sa.5, ss.630-635, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 135 Sayı: 5
  • Basım Tarihi: 2012
  • Dergi Adı: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.630-635
  • Anahtar Kelimeler: Antinociceptive effect, gabapentin, mice, nNOS, PGE(2), rat hippocampus slices, NITRIC-OXIDE, RAT CEREBELLUM, RECEPTOR, ANTICONVULSANT, ACID
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background & objectives: Several studies have shown the possible analgesic effects of gabapentin, widely used as an antiepileptic. Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats.