Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies
INDIAN JOURNAL OF MEDICAL RESEARCH, vol.135, no.5, pp.630-635, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 135 Issue: 5
- Publication Date: 2012
- Journal Name: INDIAN JOURNAL OF MEDICAL RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.630-635
- Keywords: Antinociceptive effect, gabapentin, mice, nNOS, PGE(2), rat hippocampus slices, NITRIC-OXIDE, RAT CEREBELLUM, RECEPTOR, ANTICONVULSANT, ACID
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
Background & objectives: Several studies have shown the possible analgesic effects of gabapentin, widely used as an antiepileptic. Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats.