Biotransformation of alpha-Cedrol and Caryophyllene Oxide by the Fungus Neurospora crassa

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KIRAN İ., Durceylan Z., KIRIMER N., BAŞER K. H. C., Noma Y., DEMİRCİ F.

NATURAL PRODUCT COMMUNICATIONS, vol.5, no.4, pp.515-518, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1177/1934578x1000500403
  • Journal Name: NATURAL PRODUCT COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.515-518
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Incubation of a-cedrol and caryophyllene oxide with Neurospora crassa afforded 12 beta-hydroxy cedrol, 10 alpha-hydroxy cedrol, and 3 beta-hydroxy cedrol, and 12 beta-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated in vitro using broth microdilution and bioauthographic techniques. However, no significant antibacterial and antioxidant activities were observed when compared with those of standard substances.