The harmony between the spouses is an important factor that may affect all aspects of a relationship. Marriage-related problems are an important stressor to affecting mental health. The aim of this study is to reveal the relationship between marital adjustment and sexuality with depressive symptoms in women. The study was conducted with 160 participants and the data were collected by the Arizona Sexual Experiences Scale, the General Health Questionnaire and the Marital Adjustment Test. Result of this study it was observed that as the general health status of women was disrupted and their depression risk increased, their marital adjustment decreased and they tended to have problems with sexual functions.