Current strategies for the regeneration of skeletal muscle tissue


Alarçin E., Bal‐Öztürk A., Avcı H., Ghorbanpoor H., Guzel F. D. , Akpek A., ...More

International Journal of Molecular Sciences, vol.22, no.11, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 22 Issue: 11
  • Publication Date: 2021
  • Doi Number: 10.3390/ijms22115929
  • Journal Name: International Journal of Molecular Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: skeletal muscle cells, tissue engineering, hydrogels, scaffold topographies, MESENCHYMAL STEM-CELLS, MUSCULAR-DYSTROPHY PATIENT, BONE-MARROW, SATELLITE CELLS, VOLUMETRIC MUSCLE, MYOBLAST DIFFERENTIATION, STROMAL CELLS, IN-VITRO, MYOGENIC DIFFERENTIATION, REPAIR CONSTRUCT
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physi-cochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and bio-molecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.