Rapid molecular cytogenetic diagnosis of transfusion associated graft-versus-host disease by fluorescent in situ hybridization (FISH)

Akay, Meltem; Temiz, Gokhan; ÜSKÜDAR TEKE, HAVA; GÜNDÜZ, EREN; Acikahn, MUSTAFA; IŞIKSOY, SERAP; DURAK ARAS, BEYHAN; Gulbas, Zafer

doi:10.1016/j.transci.2008.03.011

Rapid molecular cytogenetic diagnosis of transfusion associated graft-versus-host disease by fluorescent in situ hybridization (FISH)

Akay M. O., Temiz G., ÜSKÜDAR TEKE H., GÜNDÜZ E., Acikahn M. F., IŞIKSOY S., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.38, sa.3, ss.189-192, 2008 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 38 Sayı: 3
Basım Tarihi: 2008
Doi Numarası: 10.1016/j.transci.2008.03.011
Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.189-192
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Transfusion associated graft-versus-host disease (TA-GVHD) is a rare, dreadful complication of transfusion in immunocompromized and immunologically competent individuals. The diagnosis is often delayed, because of lack of awareness and the non-specific clinical features. We describe a rapid molecular cytogenetic analysis of FISH for the diagnosis of two cases of TA-GVHD with sex-mismatched donors. The use of FISH is a rapid and sensitive technique for the early diagnosis of TA-GVHD when the recipient and donor are of different gender. (C) 2008 Published by Elsevier Ltd.