Rapid molecular cytogenetic diagnosis of transfusion associated graft-versus-host disease by fluorescent in situ hybridization (FISH)


Akay M. O., Temiz G., ÜSKÜDAR TEKE H., GÜNDÜZ E., Acikahn M. F., IŞIKSOY S., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.38, no.3, pp.189-192, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.transci.2008.03.011
  • Journal Name: TRANSFUSION AND APHERESIS SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.189-192
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Transfusion associated graft-versus-host disease (TA-GVHD) is a rare, dreadful complication of transfusion in immunocompromized and immunologically competent individuals. The diagnosis is often delayed, because of lack of awareness and the non-specific clinical features. We describe a rapid molecular cytogenetic analysis of FISH for the diagnosis of two cases of TA-GVHD with sex-mismatched donors. The use of FISH is a rapid and sensitive technique for the early diagnosis of TA-GVHD when the recipient and donor are of different gender. (C) 2008 Published by Elsevier Ltd.