Rapid molecular cytogenetic diagnosis of transfusion associated graft-versus-host disease by fluorescent in situ hybridization (FISH)

Akay M. O. , Temiz G., ÜSKÜDAR TEKE H. , GÜNDÜZ E. , Acikahn M. F. , IŞIKSOY S. , ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.38, sa.3, ss.189-192, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.transci.2008.03.011
  • Sayfa Sayıları: ss.189-192


Transfusion associated graft-versus-host disease (TA-GVHD) is a rare, dreadful complication of transfusion in immunocompromized and immunologically competent individuals. The diagnosis is often delayed, because of lack of awareness and the non-specific clinical features. We describe a rapid molecular cytogenetic analysis of FISH for the diagnosis of two cases of TA-GVHD with sex-mismatched donors. The use of FISH is a rapid and sensitive technique for the early diagnosis of TA-GVHD when the recipient and donor are of different gender. (C) 2008 Published by Elsevier Ltd.