Practical Alternatives To Modeling-Based Nerve Conduction Velocity Distribution Methods

Uluslararası Tıp Bilimleri ve Multidisipliner Yaklasımlar Kongresi, İstanbul, Türkiye, 20 - 21 Şubat 2021, ss.553

Nerve conduction velocity measurement is an essential method used clinically to diagnose

many neuropathies and to monitor their progression. Calculation of nerve conduction velocity distribution

(NCVD) is a method that provides much more information and has the potential to be used in

clinical practice. During the development of neuropathies, nerve fibers that conduct at different velocities

are affected first, causing a delay in diagnosis. In this respect, the NCVD calculation is very promising.

However, unfortunately, difficulties in post-recording processes reduce its preferability. Calculation

methods using single fiber action potential (SFAP) models based on the volume conductor theory

give the most detailed NCVD results. However, in practice, difficulties arise in its applicability by a

technician or physician. Collision and Fourier Analysis methods, which require less complex calculations

and can be used relatively more practically, stand out as useful alternatives. In this study, it is aimed

to determine the usability and deficiencies or weaknesses of the two methods in order to determine

NCVD. For this purpose, the findings we have obtained with these methods are compared with the

results of NCVD based on the modeling we obtained in our previous experimental studies. It has been

seen that the Collision method provides more detailed information than the Fourier Analysis. However,

since two stimuli application and periodic Interstimulus Interval change are required, it costs more time

during recording. Fourier Analysis, on the other hand, is inadequate to show the change in the activity

of certain fiber groups, but generally gives results compatible with NCVD calculations based on modeling.

As a result, Fourier Analysis seems to be usable as a practical alternative, although it does not

provide as much detailed information as modeling-based NCVD calculations.

Keywords: Conduction Velocity Distribution, Collision Technique, Fourier Analysis, Peripheral Nerve,

Neuropathy