Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

Tokac M., Aydin S., Taner G., Ozkardes A. B., Yavuz Taslipinar M., Dogan M., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.4, ss.857-864, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1404-57
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.857-864
  • Anahtar Kelimeler: Lycopene, cholestasis, DNA damage, oxidative stress, peripheral lymphocytes, liver, RENAL OXIDATIVE STRESS, BILE-DUCT LIGATION, DNA-DAMAGE, OBSTRUCTIVE-JAUNDICE, HEPATIC-INJURY, LIVER, RATS, LYMPHOCYTES, MECHANISMS, MELATONIN
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats.