TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.4, pp.857-864, 2015 (Journal Indexed in SCI)
Article / Article
Title of Journal :
TURKISH JOURNAL OF MEDICAL SCIENCES
Lycopene, cholestasis, DNA damage, oxidative stress, peripheral lymphocytes, liver, RENAL OXIDATIVE STRESS, BILE-DUCT LIGATION, DNA-DAMAGE, OBSTRUCTIVE-JAUNDICE, HEPATIC-INJURY, LIVER, RATS, LYMPHOCYTES, MECHANISMS, MELATONIN
Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats.