Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation


ÖZDEMİR A., Turan-Zitouni G., KAPLANCIKLI Z. A.

TURKISH JOURNAL OF CHEMISTRY, cilt.32, sa.5, ss.529-538, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Konu: 5
  • Basım Tarihi: 2008
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.529-538

Özet

Fourteen new 1-[(N, N-disubstitutedthiocarbamoylthio) acetyl]-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and appropriate sodium salts of N, N-disubstituted dithiocarbamoic acids in acetone. The structures of the synthesized compounds were confirmed by UV, IR, H-1-NMR, and FAB(+)-MS spectral data. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.