EVALUATION OF GENOTOXIC EFFECTS OF TWO POLYCYCLIC AROMATIC HYDROCARBONS WITH ALLIUM TEST

KORKMAZ F., GÖMÜRGEN A. N., Mercangoz A.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.18, sa.12, ss.2306-2311, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 12
  • Basım Tarihi: 2009
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2306-2311
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In the present study, the genotoxicity risks of two 9-aryl substituted phenanthrene derivates synthesized as drug precursors were tested with Allium test. 9-(5-nitro-1H-benzimidazol-2-yl) phenanthren decreased the mitotic index (MI), and increased chromosome aberrations, among them C-metaphase, sticky metaphase, disturbed metaphase, lost chromosome at metaphase, polyploidy, disturbed anaphase, anaphase bridge, anaphase bridge with lost chromosome, chromosome break at anaphase and micronuclei formation. 9-(5-nitro-1H-benzimidazol-2-yl) phenanthrene has shown genotoxic effects, while 9-(phenanthro [9,10-d] imidazol-2-yl) phenanthrene had not any genotoxic effect.