Synthesis of Ethynyl-Thiophene Derivatives, Antioxidant Properties and ADME Analysis

Konuş M., Algso M., Yılmaz C., Khorsheed B. A., Köroğlu A., Çetin D., ...More

ChemistrySelect, vol.7, no.12, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 12
  • Publication Date: 2022
  • Doi Number: 10.1002/slct.202200281
  • Journal Name: ChemistrySelect
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Keywords: Ethynyl-thiophene, cross-coupling reaction, reducing power, antioxidant capacity, ADME, T, RADICALS
  • Eskisehir Osmangazi University Affiliated: Yes


© 2022 Wiley-VCH GmbH.Herein, novel alkyne based organic compounds, 2-((2-(methylthio)phenyl)ethynyl)thiophene (MAT) and 2-ethynyl-3-(phenylethynyl)thiophene (DAT), were designed and synthesized via Pd-catalyst cross-coupling reactions. The isolated yields of MAT and DAT were obtained as 77 % and 96 %, respectively. After chemical characterization, radical scavenging activities and reduction power capacities of them were determined by DPPH, TEAC, phosphomolybdenum and reducing power methods. MAT showed higher radical scavenging activities than DAT, and comparable with the standard. Moreover, basic ADME properties were calculated in silico. Both of the newly synthesized derivatives were reported with the same moderate to good drug score of 0.42; and, having potential to pass through BBB and GI with no appointed toxic effects.