Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene

Zeytinoglu H., Incesu Z., Baser K.

PHYTOMEDICINE, vol.10, no.4, pp.292-299, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1078/094471103322004785
  • Journal Name: PHYTOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.292-299
  • Eskisehir Osmangazi University Affiliated: No


Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional distillation of Origanum onites L. essential oil, on DNA synthesis of N-ras transformed myoblast cells, CO25. Incubation of the cells with different doses of carvacrol prevented DNA synthesis in the growth medium and ras-activating medium, which contains dexamethasone. This result demonstrates that carvacrol inhibits growth of myoblast cells even after activation of mutated N-ras oncogene, suggesting the possibility that carvacrol may find application in cancer therapy.