Akademik Veri Yönetim Sistemi
CYPRUS JOURNAL OF MEDICAL SCIENCES, cilt.11, sa.2, ss.128-135, 2026 (ESCI, TRDizin)
BACKGROUND/AIMS In animal experiments, carbon tetrachloride (CCl4) is commonly used to produce hepatotoxicity because it induces oxidative stress. Increased production of reactive oxygen species, resulting in oxidative stress, has detrimental effects on several cellular components. Lavandula angustifolia oil has been recognized as an indirect antioxidant that boosts the activity and expression of antioxidant enzymes. Medical ozone therapy, which uses appropriate concentrations of ozone, is being investigated for its potential to treat and prevent hepatotoxicity and other conditions. The effects of medical ozone, lavender, and the combined effects of both therapies on sperm morphology and count in hepatotoxic rats were examined in this study. MATERIALS AND METHODS CCl4 was used to cause acute hepatotoxicity in Wistar rats and sperm cells were obtained from - extracted epididymal structure. Then, the Spermac Kit (FertiPro Spermac Stain) was used to analyze sperm morphology after medical ozone, lavender, and combined treatment. RESULTS Adding lavender to the treatment increased sperm count (p<0.001), irrespective of medical ozone. However, the sperm count is unaffected when lavender and medical ozone are combined (p>0.05). However, The total number of defects in the head, neck, and tail varies among the three groups' sperm morphologies. CONCLUSION Only the rats who received Lavandula angustifolia oil treatment showed an increase in spermatozoa, suggesting that medical ozone may counteract Lavandula's effects. Therefore, this study is crucial to understanding the relationship between medical ozone and lavender oil.