The effect of drip versus intermittent feeding on splanchnic oxygenation in preterm infants with intrauterine growth restriction: a prospective randomized trial

Surmeli Onay Ö., Velipasaoğlu M., Tutal M., Sarılar T. D., Cakıl Saglık A., Bilgin M., ...Daha Fazla

EUROPEAN JOURNAL OF PEDIATRICS, cilt.182, sa.3, ss.1317-1328, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 182 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00431-023-04810-x
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE
  • Sayfa Sayıları: ss.1317-1328
  • Anahtar Kelimeler: Fetal superior mesenteric artery, Intrauterine growth restriction, Drip feeding, Intermittent feeding, Regional splanchnic saturation, Umbilical catheter, SUPERIOR MESENTERIC-ARTERY, NEAR-INFRARED SPECTROSCOPY, BLOOD-FLOW VELOCITIES, NECROTIZING ENTEROCOLITIS, TISSUE OXYGENATION, MECONIUM PASSAGE, UMBILICAL ARTERY, VELOCIMETRY, CIRCULATION, SATURATION
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The main purpose of this study was to evaluate the impact of drip versus intermittent feeding on splanchnic oxygenation in preterm infants with intrauterine growth restriction. The second objective was to assess the relationship between fetal splanchnic circulation parameters and splanchnic oxygenation during the first week of life. A single-center, prospective, randomized study with 51 fetuses/infants was conducted. Fetal Doppler measurements including umbilical artery, middle cerebral artery, and superior mesenteric artery (SMA) were recorded in IUGR fetuses. After preterm delivery, the infants were randomly assigned to one of two feeding modalities: drip (3-h continuous) or intermittent (bolus in 10 min). Continuous regional splanchnic saturation (rSO(2)S) monitoring was carried out during the first week of life, simultaneously with continuous oxygen arterial saturation (SaO(2)) monitoring, and the infants' fractional oxygen extractions (FOE) were calculated. These parameters were evaluated as means on a daily basis for the first week of life, as well as pre-prandial and post-prandial measurements on the seventh day. Fetal Doppler flow velocimetry disturbances were present in 72.5% of the study cohort. The drip (26 infants) and intermittent (25 infants) groups were similar in demographic and clinical characteristics, as well as the prevalence of feeding intolerance and necrotizing enterocolitis. During the first week of life, there was no difference in daily mean rSO(2)S and FOE values between the drip and intermittent groups, whereas unfed infants had mostly lower rSO(2)S values. Pre-prandial and post-prandial rSO(2)S values remained stable in both groups. Also, no association was detected between fetal splanchnic circulation parameters and neonatal splanchnic oxygenation. RSO2S values were strongly correlated to gestational age and birth weight. During the whole week, except for the first 2 days, infants with umbilical catheters had significantly lower rSO(2)S values than infants without. Conclusion: Our data suggest that the key factor in splanchnic oxygenation is feeding, not the feeding modality. In addition, the umbilical vein catheter had a negative impact on splanchnic oxygenation.