Effects of Carnosine (Beta-Alanyl-L-Histidine) in an Experimental Rat Model of Acute Kidney Injury Due to Septic Shock


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ŞAHİN S. , BURUKOĞLU DÖNMEZ D.

MEDICAL SCIENCE MONITOR, vol.24, pp.305-316, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24
  • Publication Date: 2018
  • Doi Number: 10.12659/msm.905181
  • Title of Journal : MEDICAL SCIENCE MONITOR
  • Page Numbers: pp.305-316

Abstract

Background: Acute kidney injury (AKI) secondary to sepsis is a major cause of morbidity and mortality in the human intensive care unit (ICU). Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).