Effects of Carnosine (Beta-Alanyl-L-Histidine) in an Experimental Rat Model of Acute Kidney Injury Due to Septic Shock

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ŞAHİN S., BURUKOĞLU DÖNMEZ D.

MEDICAL SCIENCE MONITOR, cilt.24, ss.305-316, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24
  • Basım Tarihi: 2018
  • Doi Numarası: 10.12659/msm.905181
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.305-316
  • Anahtar Kelimeler: Acute Kidney Injury, Carnosine, Shock, Septic, EXPERIMENTAL SEPSIS, LIVER, FAILURE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Acute kidney injury (AKI) secondary to sepsis is a major cause of morbidity and mortality in the human intensive care unit (ICU). Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).