The effects of short-term use of granulocyte colony-stimulating factor on bone metabolism in child cancer patients


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Turhan A. B. , Binay C., BÖR Ö. , ŞİMŞEK E.

NORTHERN CLINICS OF ISTANBUL, vol.5, no.4, pp.277-281, 2018 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.14744/nci.2017.59320
  • Title of Journal : NORTHERN CLINICS OF ISTANBUL
  • Page Numbers: pp.277-281
  • Keywords: Bone, cancer, granulocyte colony-stimulating factor, hematopoietic growth factor, PERIPHERAL-BLOOD STEM, BIOCHEMICAL MARKERS, OSTEOPOROSIS, OVEREXPRESSION, NEUTROPENIA, INHIBITION, GROWTH, CSF

Abstract

OBJECTIVE: The granulocyte colony-stimulating factor (G-CSF) is the most commonly used hematopoietic growth factor recombinant DNA technology. It affects bone metabolism by modulating both osteoclast and osteoblast functions. The aim of the present study was to investigate the effects of short-term use of G-CSF on bone metabolism in children with leukemia and solid tumors.