Objective: This study is carried out in order to find out the knowledge, attitudes, behaviors, anxieties and reservations of 1st and 3rd year students in the Faculty of Medicine, Eskisehir Osmangazi University and 1st year students in the Faculty of Law Anadolu University about organ donation and transplantation. Material and Methods: Participants responded to the questions in the questionnaire related to the organ donation and transplantation. Arithmetic mean, standard deviation, frequency, percentages and t test were used to analyze the data. Results: In our study, 116 1st year students in the Faculty of Medicine (74.4%), 403rd year students in the Faculty of Medicine (68.9%) and 88 1st year students in the Faculty of Law (69.3%) state that they do not know where the organs are donated. It is found out that 130 1st year students the Faculty of Medicine (83.3%), 44 students in the 3rd year of the Faculty of Medicine (75.9%) and 91 students in the 1st year of the Faculty of Law (71.1%) do not know Law About the Taking, Storing, Grafting and Transplantation of Organs and Tissue, Law no. 2238. Conclusion: It is found out that students' attitudes towards organ donation and transplantation are shaped on the basis of personal emotions, and that they do not have sufficient medical and legal knowledge about this issue. Despite the insufficiency of medical and legal knowledge, since the thought of helping people who are in need is among the first factors which influence the decision of organ donation, it is clear that the values which uphold human beings contribute to willingness to organ donation.