Synthesis and cytotoxic and analgesic activities of some 1,5-diaryl-3-ethoxycarbonylpyrrole derivatives

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Demirayak S., Beis R., Karaburun A., Kayagil I., Incesu Z., Ucucu U.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.21, no.1, pp.113-118, 2006 (SCI-Expanded) identifier identifier identifier


Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the compounds were determined by using the tail-flick and tail-immersion methods; some of the compounds showed potent analgesic activity.