Synthesis and cytotoxic and analgesic activities of some 1,5-diaryl-3-ethoxycarbonylpyrrole derivatives

Demirayak, S; Beis, R; Karaburun, AC; Kayagil, I; Incesu, Z; Ucucu, U

doi:10.1080/14756360500472845

Synthesis and cytotoxic and analgesic activities of some 1,5-diaryl-3-ethoxycarbonylpyrrole derivatives

Atıf İçin Kopyala

Demirayak S., Beis R., Karaburun A., Kayagil I., Incesu Z., Ucucu U.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.21, sa.1, ss.113-118, 2006 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 1
Basım Tarihi: 2006
Doi Numarası: 10.1080/14756360500472845
Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.113-118
Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the compounds were determined by using the tail-flick and tail-immersion methods; some of the compounds showed potent analgesic activity.