The purpose of this study is to put forth the conclusions of a validity and reliability study for a measurement tool which aims to measure the perceptions of teaching candidates directed at 21st century skills. Considering development process (scanning literature, creating item pool, givining to experts within the area, pre-trial, the determination construct validity) final form of the scale of development. To determine the validity of the draft scale; the data obtained from 330 of the teaching candidates were used for exploratory factor analysis and 330 were used for confirmatory factor analysis. As a result of the factor analysis 42 items remained in the draft scale and these items were collected together under three factors (Learning and Innovation, Skills, Life and Career Skills, and Information, Media and Technology Skills). It was determined through the compliance determinants of the confirmatory factor analysis that the 21st century skills competence scale was comprised of 42 items and this model was found to be appropriate both from the organisational and from the statistical point of view. As a result, it has been shown in the validity and reliability study of the 21st Century skills scale, which had been developed directed at teaching candidates, that the scale possesses a sufficient level of psychometric characteristics.