Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury

Bal, Fatih; BEKPINAR, Seldağ; Unlucerci, Yesim; Kusku-Kiraz, ZEYNEP; Onder, Semen; Uysal, Mujdat; Gurdol, Figen

doi:10.1016/j.diabres.2014.08.028

Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury

Bal F., BEKPINAR S., Unlucerci Y., Kusku-Kiraz Z., Onder S., Uysal M., ...Daha Fazla

DIABETES RESEARCH AND CLINICAL PRACTICE, cilt.106, sa.2, ss.295-302, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 106 Sayı: 2
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.diabres.2014.08.028
Dergi Adı: DIABETES RESEARCH AND CLINICAL PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.295-302
Anahtar Kelimeler: Asymmetric dimethylarginine, Inflammation, Metformin, Arginine, Dimethylarginine dimethylaminohydrolase, Liver injury, NITRIC-OXIDE SYNTHASE, DIABETES-MELLITUS, PLASMA-CONCENTRATIONS, ARGININE METHYLATION, ADMA, LPS, ENDOTOXIN, MACROPHAGES, HYPOTHESIS, INHIBITOR
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Aims: We aimed to investigate the pharmacological efficiency of metformin on asymmetric dimethylarginine (ADMA) metabolism in inflammation caused by the lipopolysaccharide (LPS)/D-galactosamine (D-GalN) treatment.