Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury


Bal F., BEKPINAR S., Unlucerci Y., Kusku-Kiraz Z., Onder S., Uysal M., ...Daha Fazla

DIABETES RESEARCH AND CLINICAL PRACTICE, cilt.106, sa.2, ss.295-302, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 106 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.diabres.2014.08.028
  • Dergi Adı: DIABETES RESEARCH AND CLINICAL PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.295-302
  • Anahtar Kelimeler: Asymmetric dimethylarginine, Inflammation, Metformin, Arginine, Dimethylarginine dimethylaminohydrolase, Liver injury, NITRIC-OXIDE SYNTHASE, DIABETES-MELLITUS, PLASMA-CONCENTRATIONS, ARGININE METHYLATION, ADMA, LPS, ENDOTOXIN, MACROPHAGES, HYPOTHESIS, INHIBITOR
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Aims: We aimed to investigate the pharmacological efficiency of metformin on asymmetric dimethylarginine (ADMA) metabolism in inflammation caused by the lipopolysaccharide (LPS)/D-galactosamine (D-GalN) treatment.