Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury


Bal F., BEKPINAR S., Unlucerci Y., Kusku-Kiraz Z., Onder S., Uysal M., ...More

DIABETES RESEARCH AND CLINICAL PRACTICE, vol.106, no.2, pp.295-302, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 106 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.diabres.2014.08.028
  • Journal Name: DIABETES RESEARCH AND CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.295-302
  • Keywords: Asymmetric dimethylarginine, Inflammation, Metformin, Arginine, Dimethylarginine dimethylaminohydrolase, Liver injury, NITRIC-OXIDE SYNTHASE, DIABETES-MELLITUS, PLASMA-CONCENTRATIONS, ARGININE METHYLATION, ADMA, LPS, ENDOTOXIN, MACROPHAGES, HYPOTHESIS, INHIBITOR
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Aims: We aimed to investigate the pharmacological efficiency of metformin on asymmetric dimethylarginine (ADMA) metabolism in inflammation caused by the lipopolysaccharide (LPS)/D-galactosamine (D-GalN) treatment.