Serum soluble endothelial-cell specific adhesion molecules in children with insulin-dependent diabetes mellitus

Dogruel N., Kirel B., Akgun Y., Us T.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.14, no.3, pp.287-293, 2001 (SCI-Expanded) identifier identifier identifier


Endothelial-cell specific adhesion molecules are reported to be elevated in patients with diabetes mellitus and related to diabetic vascular complications. We studied serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), endothelial-leukocyte adhesion molecule (sE-selectin) in 30 healthy children and 35 children with type 1 diabetes without symptomatic vascular complications. sE-selectin levels were higher in diabetics than in controls (p < 0.001), sVCAM-1 and sICAM-1 levels were not different between the groups (p > 0,05), In seven newly diagnosed diabetics with ketoacidosis, concentrations of these molecules were not different before and after one month of insulin therapy (p > 0,05), In the combined group, only sE-selectin was correlated positively with serum glucose, HbA(1c) (r = 0,3, p < 0.05 for both) and negatively with C-peptide levels (r -0,4, p < 0.05), In diabetic children without symptomatic vascular complications, sE-selectin but not sICAM and sVCAM levels was elevated; this finding might reflect ongoing endothelial-cell activation rather than endothelial damage.