Serum soluble endothelial-cell specific adhesion molecules in children with insulin-dependent diabetes mellitus

Dogruel N., Kirel B. , Akgun Y., Us T.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.14, no.3, pp.287-293, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1515/jpem.2001.14.3.287
  • Page Numbers: pp.287-293


Endothelial-cell specific adhesion molecules are reported to be elevated in patients with diabetes mellitus and related to diabetic vascular complications. We studied serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), endothelial-leukocyte adhesion molecule (sE-selectin) in 30 healthy children and 35 children with type 1 diabetes without symptomatic vascular complications. sE-selectin levels were higher in diabetics than in controls (p < 0.001), sVCAM-1 and sICAM-1 levels were not different between the groups (p > 0,05), In seven newly diagnosed diabetics with ketoacidosis, concentrations of these molecules were not different before and after one month of insulin therapy (p > 0,05), In the combined group, only sE-selectin was correlated positively with serum glucose, HbA(1c) (r = 0,3, p < 0.05 for both) and negatively with C-peptide levels (r -0,4, p < 0.05), In diabetic children without symptomatic vascular complications, sE-selectin but not sICAM and sVCAM levels was elevated; this finding might reflect ongoing endothelial-cell activation rather than endothelial damage.