Synthesis and Characterization of New Binaphthyl-Linked Phenanthroline-, Bipyridine-, or Pyridine-Derived Ligands, and the Study of Their Cytotoxic Activity

Beynek N., Ulucam G., BENKLİ K., KOPARAL A. T.

HELVETICA CHIMICA ACTA, vol.91, no.11, pp.2089-2096, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 91 Issue: 11
  • Publication Date: 2008
  • Doi Number: 10.1002/hlca.200890223
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2089-2096
  • Eskisehir Osmangazi University Affiliated: No


In the present work, we describe the synthesis and characterization of five new versatile acyclic or macrocyclic ligands containing binaphtyl-linked pyridine, bipyridine, or phenanthroline groups in their framework (see Schemes 1-4). The structures of the ligands were elucidated on the basis of elemental analyses. 1R, (1)H-NMR, (13)C-NMR, and FAB mass spectra. The cytotoxicity of these compounds was tested in vitro by using the tetrazolium salt reduction (MTT) assay on A549 (human lung carcinoma epithelial like) cells. All Of the tested compounds induced time- and concentration-dependent cytotoxic effect.