Positive inotropic, positive chronotropic and coronary vasodilatory effects of rat amylin: mechanisms of amylin-induced positive inotropy

Kaygisiz Z., Ozden H., Erkasap N., Koken T., Gunduz T., Ikizler M., ...More

ACTA PHYSIOLOGICA HUNGARICA, vol.97, no.4, pp.362-374, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 97 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1556/aphysiol.97.2010.4.2
  • Journal Name: ACTA PHYSIOLOGICA HUNGARICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.362-374
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Even though there are a few studies dealing with the cardiac effects of amylin, the mechanisms of amylin-induced positive inotropy are not known well. Therefore, we investigated the possible signaling pathways underlying the amylin-induced positive inotropy and compared the cardiac effects of rat amylin (rAmylin) and human amylin (hAmylin).