A study of the possible association of plasminogen activator inhibitor type 1 4G/5G insertion/deletion polymorphism with susceptibility to schizophrenia and in its subtypes

Yenilmez C., Koroglu Z. O., KURT H., Yanas M., Colak E., DEĞİRMENCİ İ., ...More

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, vol.42, no.1, pp.103-107, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1111/jcpt.12470
  • Journal Name: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.103-107
  • Keywords: PAI-1 4G, 5G polymorphism, schizophrenia, MAJOR DEPRESSION, GENE PROMOTER, PAI-1, THROMBOSIS, FIBRINOLYSIS, GENOTYPE, SYSTEM, ACE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

What is known and objectiveInhibition of the fibrinolytic system may occur at the level of plasminogen activation, mainly by PAI-1. Mental and physical stress caused to alterations of platelet function, and also decreased to fibrinolytic activity. Furthermore, stress-induced thrombosis regulation was proposed to be by PAI-1 in schizophrenia patients. In this study, the distribution of genotypes and frequency of alleles of the plasminogen activator inhibitor type 1 (PAI-1) gene 4G/5G polymorphism in different Turkish clinical schizophrenia subtypes was investigated for its role in schizophrenia development.