Akademik Veri Yönetim Sistemi
EPHAR 2024, Athens, Yunanistan, 23 - 26 Haziran 2024, ss.21
Objectives: Drugs
in the treatment of schizophrenia are mostly effective on positive symptoms of the disease while have
limited effectiveness on negative and cognitive symptoms; new mechanisms and
treatment targets are being investigated. Pregabalin is used in the treatment
of epilepsy, postherpetic neuralgia, diabetic neuropathy, fibromyalgia and exerts
its effect by binding to the alpha-2-delta subunit of voltage-gated calcium
channels located presynaptically in the central nervous system and reduces the
release of excitatory neurotransmitters.
We aimed to investigate
the effects of acute pregabalin administration on experimental schizophrenia
models in rats.
Materials-Methods:
Wistar-albino male rats(200-250g) were used in experimental schizophrenia models
as MK-801(0.3mg/kg;i.p.)-induced hyperlocomotion and prepulse inhibition (PPI).
Pregabalin(30,100mg/kg;i.p.) were administered acutely 1 hour before the tests.
The effect of pregabalin was compared with the antipsychotics haloperidol(1mg/kg;i.p.)
and olanzapine(3mg/kg;i.p.). Statistical analysis were performed by using One-way
ANOVA.
Results:
In hyperlocomotion test, MK-801 significantly increased the distance traveled compared
to the control(p<0.01). Pregabalin(30,100mg/kg) significantly reduced the
distance traveled compared to MK-801(p=0.001;p<0.001,respectively). Both
doses showed similar effects. Haloperidol and olanzapine significantly reduced
the distance traveled compared to MK-801(p<0.001;p<0.01,respectively)
being more significantly with haloperidol than olanzapine(p<0.05). The
effects of both doses of pregabalin on the locomotor activity test were similar
to antipsychotics(p>0.05). In the PPI test, MK-801 significantly reduced the
PPI% at prepulse levels of 74,78,86dB
compared to control(p<0.05;p<0.01; p<0.01,respectively). Both doses of
pregabalin and haloperidol significantly increased the PPI% compared to MK-801, at 86dB(p<0.05)
similarly. Although olanzapine increased the PPI% compared to MK-801 at 86dB,
this didn’t reach statistical significance(p>0.05).
Conclusions: We
suggest that pregabalin may have an antipsychotic-like effect and glutamatergic
transmission may be involved in this effect.
Keywords: Pregabalin,
MK-801, apomorphine, experimental schizophrenia models
This study was supported
by Eskişehir Osmangazi University Scientific Research Projects Coordination
Unit within the scope of project number 2586.