Low dose chemotherapeutic drugs without overt cytotoxic effects decrease the secretion of VEGF by cultured human tumor cells: A tentative relationship between drug type and tumor cell type response

Aktas S. H. , Akbulut H., Akgun N., Icli F.

CANCER BIOMARKERS, vol.12, no.3, pp.135-140, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.3233/cbm-130301
  • Title of Journal : CANCER BIOMARKERS
  • Page Numbers: pp.135-140


BACKGROUND: The metronomic use of chemotherapeutic drugs is presumed to have anti-angiogenic effect. In the current study, we aimed to test the effects of lower doses of cytotoxic agents on VEGF secretion from tumor cell lines.