Low dose chemotherapeutic drugs without overt cytotoxic effects decrease the secretion of VEGF by cultured human tumor cells: A tentative relationship between drug type and tumor cell type response

Aktas, SEDEF; Akbulut, Hakan; Akgun, Nalan; Icli, Fikri

doi:10.3233/cbm-130301

Low dose chemotherapeutic drugs without overt cytotoxic effects decrease the secretion of VEGF by cultured human tumor cells: A tentative relationship between drug type and tumor cell type response

Aktas S. H., Akbulut H., Akgun N., Icli F.

CANCER BIOMARKERS, cilt.12, sa.3, ss.135-140, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 12 Sayı: 3
Basım Tarihi: 2012
Doi Numarası: 10.3233/cbm-130301
Dergi Adı: CANCER BIOMARKERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.135-140
Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

BACKGROUND: The metronomic use of chemotherapeutic drugs is presumed to have anti-angiogenic effect. In the current study, we aimed to test the effects of lower doses of cytotoxic agents on VEGF secretion from tumor cell lines.