Protective effects of anandamide against cisplatin-induced peripheral neuropathy in rats

Çengelli Ünel Ç., Dönertaş B., Aydin Ş., Ulupinar E., Özatik O., Kaygisiz B., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.6, ss.3098-3107, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2101-224
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.3098-3107
  • Anahtar Kelimeler: Cis-diamminedichloroplatinum(II), n-arachidonoylethanolamide, ng nitroarginine methyl ester, nitric oxide, peripheral neuropathy, ROOT GANGLION NEURONS, ACID AMIDE HYDROLASE, NITRIC-OXIDE, CANNABINOID RECEPTOR, SCIATIC-NERVE, REDUCES PAIN, NEUROTOXICITY, HYPERALGESIA, INHIBITION, MODEL
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background/aim: Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy is a major dose-limiting side-effect in CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated the analgesic effects of anandamide (AN) on CIS-induced peripheral neuropathy, in vitro effects of AN in CIS neurotoxicity, and the contribution of nitric oxide (NO) in this effect.