TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.6, pp.3098-3107, 2021 (SCI-Expanded)
Article / Article
TURKISH JOURNAL OF MEDICAL SCIENCES
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
Cis-diamminedichloroplatinum(II), n-arachidonoylethanolamide, ng nitroarginine methyl ester, nitric oxide, peripheral neuropathy, ROOT GANGLION NEURONS, ACID AMIDE HYDROLASE, NITRIC-OXIDE, CANNABINOID RECEPTOR, SCIATIC-NERVE, REDUCES PAIN, NEUROTOXICITY, HYPERALGESIA, INHIBITION, MODEL
Eskisehir Osmangazi University Affiliated:
Background/aim: Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy is a major dose-limiting side-effect in CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated the analgesic effects of anandamide (AN) on CIS-induced peripheral neuropathy, in vitro effects of AN in CIS neurotoxicity, and the contribution of nitric oxide (NO) in this effect.