Protective effects of anandamide against cisplatin-induced peripheral neuropathy in rats

Çengelli Ünel Ç., Dönertaş B., Aydin Ş., Ulupinar E., Özatik O., Kaygisiz B., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.6, pp.3098-3107, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2101-224
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.3098-3107
  • Keywords: Cis-diamminedichloroplatinum(II), n-arachidonoylethanolamide, ng nitroarginine methyl ester, nitric oxide, peripheral neuropathy, ROOT GANGLION NEURONS, ACID AMIDE HYDROLASE, NITRIC-OXIDE, CANNABINOID RECEPTOR, SCIATIC-NERVE, REDUCES PAIN, NEUROTOXICITY, HYPERALGESIA, INHIBITION, MODEL
  • Eskisehir Osmangazi University Affiliated: Yes


Background/aim: Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy is a major dose-limiting side-effect in CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated the analgesic effects of anandamide (AN) on CIS-induced peripheral neuropathy, in vitro effects of AN in CIS neurotoxicity, and the contribution of nitric oxide (NO) in this effect.