Protective effects of anandamide against cisplatin-induced peripheral neuropathy in rats
TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.6, ss.3098-3107, 2021 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 6
- Basım Tarihi: 2021
- Doi Numarası: 10.3906/sag-2101-224
- Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.3098-3107
- Anahtar Kelimeler: Cis-diamminedichloroplatinum(II), n-arachidonoylethanolamide, ng nitroarginine methyl ester, nitric oxide, peripheral neuropathy, ROOT GANGLION NEURONS, ACID AMIDE HYDROLASE, NITRIC-OXIDE, CANNABINOID RECEPTOR, SCIATIC-NERVE, REDUCES PAIN, NEUROTOXICITY, HYPERALGESIA, INHIBITION, MODEL
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Background/aim: Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy is a major dose-limiting side-effect in CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated the analgesic effects of anandamide (AN) on CIS-induced peripheral neuropathy, in vitro effects of AN in CIS neurotoxicity, and the contribution of nitric oxide (NO) in this effect.